NAD+ and Aging
Why NAD+ levels change with age, and what that means for how you feel.
Time
Bodies change with age. Your cells do too.
NAD+
A key coenzyme that naturally declines over time.
Our approachSupport
Daily NAD+ replenishment is one strategy for healthy aging.
In brief
The Quick Read
- Aging is a cellular process.How your cells work over time shapes how you feel.
- NAD+ levels naturally decline.About 50% of NAD+ may be lost as early as your 40s.
- That decline has been linked to broader changes.NAD+ depletion has been linked to mitochondrial dysfunction, a recognized hallmark of aging.
- This is why NAD+ support is studied.Replenishing NAD+ has become a well-researched healthy-aging approach.
- ReVive is designed around that idea.RiaGev®, our clinically studied ingredient, is designed to support NAD+, ATP, and glutathione together.
Healthy aging is about supporting how you feel and function as the years go on. It is not about reversing aging.
What We Mean by “Healthy Aging”
There is a difference between how many years you have lived and how you feel while you live them. “Healthy aging” is the idea that daily choices, movement, sleep, nutrition, and increasingly, supplementation, can help support how well your body functions over time.
NAD PLUS is built around one specific part of that picture: helping support the cellular machinery that produces energy and helps cells respond to stress.
What Happens to NAD+ Over Time
Your NAD+ levels are not fixed. They shift with age.
of NAD+ may be lost as early as your 40s.
This decline has been described across the published literature and is one of the reasons NAD+ has become a focus in healthy-aging research.
As NAD+ levels shift, your cells’ ability to produce energy and respond to everyday stress can shift with them.
Source: Bioenergy Life Science RiaGev® White Paper, 2022; Summary of the History of B3 in Wellbeing (literature review).
The bigger picture
NAD+ and the Broader Picture of Aging
NAD+ is part of several processes that researchers link to how we age.
Cellular energy
NAD+ helps your cells turn food into ATP, the energy your body actually uses.
Mitochondrial function
NAD+ depletion has been linked to mitochondrial dysfunction, a recognized hallmark of aging.
Response to stress
NAD+ is involved in how cells respond to oxidative and metabolic stress.
Cellular repair
NAD+ plays a role in the cellular processes that help maintain the health of cells over time.
NAD+ is not a single-purpose molecule. It is involved in many of the systems that determine how well cells work as we age.
Source: Bioenergy Life Science RiaGev® White Paper, 2022; Xue Y, et al. Nutrients. 2022;14:2219.
What This Can Look Like in Daily Life
You may not feel your NAD+ levels directly. What you may notice is how your day feels.
Overall vitality
How much you feel like yourself.
Energy patterns
Steadier day-long energy versus mid-day drops.
Focus and clarity
How well you stay engaged with what you are doing.
Recovery
How your body bounces back from a demanding day or workout.
Individual experience varies. NAD+ support is a long-term daily strategy, not a same-day fix.
How Supporting NAD+ Fits into Healthy Aging
Your body already knows how to make NAD+. As we age, it becomes harder to keep up with demand. Supplementing gives your cells the raw materials they use most to rebuild NAD+.
ReVive is built around RiaGev®-SR, a patented, clinically studied combination of nicotinamide and D-ribose delivered in a sustained-release format. It is designed to support the salvage pathway, the route your body relies on most to make NAD+.
Support the systems that are already there. Daily NAD+ replenishment is one part of a broader approach to healthy aging that includes movement, sleep, and nutrition.
Illustrative and simplified.
Frequently Asked Questions
Is this an anti-aging supplement?
No. ReVive is designed to support healthy aging, which means supporting how well your body functions as time passes. It is not designed to reverse aging.
When should I start taking NAD+ support?
NAD+ levels can begin to decline as early as your 30s and 40s. Many people begin daily NAD+ support during those decades, though timing is personal. If you have questions, your healthcare provider is a good place to start.
Will I look younger?
ReVive is designed to support cellular processes, not appearance-based outcomes. It is a healthy-aging supplement, not a cosmetic product.
How is this different from a general multivitamin?
Multivitamins are broad-spectrum. ReVive is focused: it targets one specific system, the NAD+ salvage pathway, with a clinically studied ingredient designed to support NAD+, ATP, and glutathione together.
Recognition
Industry-Recognized for Innovation.
NIE 2020 Gold Winner
Recognized for innovation and excellence in nutraceutical ingredients at the Nutrition Industry Executive Awards.
2024 Ingredient Idol Finalist
Selected by Natural Products Insider (SupplySide Global) as one of the most innovative new ingredients in health and wellness.
Where you'll find RiaGev® in NAD PLUS
Sustained-Release, All Day.
Keep Exploring the Science
Meet RiaGev®
The patented NAD+ builder inside ReVive, and the clinical data behind it.
Read the ingredient page
The Benefits of NAD+ Support
What daily NAD+ replenishment is designed to support, and what the research says.
NAD+ and Aging
Why NAD+ levels change with age, and what that means for how you feel.
You're hereNAD+ and Mitochondria
Why the power plants inside your cells depend on NAD+ to work well.
Cellular energyNAD+ and Cellular Energy
Why your cells need NAD+ to produce energy, and what changes as we age.
The comparisonNAD+ vs. NMN
What's the difference, and why we built ReVive around the salvage pathway.
Safety
Safety Starts with Your Provider.
Consult your provider
If you're pregnant, nursing, taking medications, or managing a medical condition, talk to your healthcare provider before starting any new supplement.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
References
Published Literature & Source Documents.
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Bioenergy Life Science. RiaGev® White Paper. 2022.
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Bioenergy Life Science. RiaGev® Long-Term Trial White Paper. 2022.
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Pharmacodynamics Study Summary of RiaGev™. American Preclinical Services and Bioenergy Life Science. March 28, 2019.
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Summary of the History of B3 in Wellbeing (literature review).