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The Biomarker Report

3 Biomarkers That Matter More After 40.

NAD+, ATP and glutathione each play an important role in how your cells produce energy, respond to oxidative stress, and function as you age. These three molecules are interconnected, which is why NAD PLUS takes a broader approach to cellular support.

Its key ingredient, RiaGev®, has been clinically studied for its ability to support NAD+, ATP and glutathione together.

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Inside this report

Three biomarkers shape how your cells produce energy and handle everyday stress after 40: NAD+, ATP and glutathione. They don't work in isolation — each one is connected to the other two. Here's what each one does, why they matter together, and how NAD PLUS supports all three in one daily tablet.

  1. NAD+The supply everything else runs onRead section →+127%NAD+ in 28 days
  2. ATPWhy you crash before the day is doneRead section →+7.3%ATP vs placebo
  3. GlutathioneWhat your recovery depends onRead section →+10.2%in 3 days
  4. How they work togetherFix one, leave two, fix nothingRead section →3 in 1one daily tablet
  5. Why most supplements missNMN & NR vs RiaGev®Read section →5/5vs 1/5 for NMN & NR
  6. The deliveryOne tablet, all dayRead section →5–8 hsteady release
01Biomarker OneNAD+

NAD+: The Supply Everything Else Runs On.

NAD+ is the first of the three biomarkers, and it plays an important role in many processes throughout your body. Energy production, cellular repair, brain function and immune function all rely on NAD+ in different ways.

The challenge is that NAD+ levels naturally decline with age. As levels decrease, your cells may have less NAD+ available for the processes that depend on it, including cellular energy production and repair.

RiaGev® is designed to support your body's natural NAD+ production. It provides nicotinamide and D-ribose, two building blocks your body can use through its existing pathways to produce NAD+.

  • Energy production
  • Cellular repair
  • Brain function
  • Immune function
NAD+ levels across timeIllustrative
HighLow
100%
Age 25Baseline
~50%
Age 45Natural decline
+0%
After 28 dayswith RiaGev®
RiaGev® more than doubles what time takes away.
0%
increase in NAD+ levels after 28 days with RiaGev® — published clinical trial
0%
NAD+ levels can decrease as you age
02Biomarker TwoATP

ATP: Why You Crash Before the Day Is Done.

NAD+ does not power your cells on its own. Instead, it plays an important role in the processes your cells use to produce ATP, the molecule often called your cells' energy currency. Think of NAD+ as part of the production process and ATP as the energy your cells can actually use.

From movement and thinking to everyday cellular functions, ATP helps provide the energy your body needs to keep going. As we age, changes in cellular energy metabolism can affect how efficiently our cells produce and use energy — one reason supporting both NAD+ and ATP is central to the RiaGev® approach.

In a published clinical trial, participants taking RiaGev® showed measurable changes in ATP within the first several days.

  • Movement
  • Thinking
  • Everyday cellular function
Energy across your dayIllustrative
ENERGY 8 AM12 PM4 PM8 PM Afternoon crash With NAD PLUS Without support
Measurable ATP changes within days in a published clinical trial.
+0%
higher ATP vs placebo on Day 5
Day0
ATP improvement had already begun
03Biomarker ThreeGlutathione

Glutathione: What Your Recovery Depends On.

Inside your cells, glutathione is working around the clock. It is one of the body's most important antioxidants, helping protect cells from oxidative stress and supporting the systems that keep them functioning normally.

Here is why that matters. Glutathione is part of the same interconnected cellular system as NAD+ and ATP. NAD-related pathways help support the processes that keep glutathione in its active, reduced form, allowing it to continue doing its job.

In the published clinical trial with RiaGev®, glutathione responded quickly. Levels increased measurably within the first three days and remained elevated at Day 5.

  • Antioxidant defense
  • Oxidative stress
  • Cell protection
Glutathione responseDays, not weeks
0%4%8%12% +10.2%by Day 3 +11.6%by Day 5 Standard NAD+ supplement
Day 1Start
Day 3+10.2%
Day 5+11.6% · fastest responder
Measurable in days, not weeks.
+0%
glutathione
in just 3 days
+0%
glutathione
by Day 5
04How theyWork together

Fix One. Leave Two. Fix Nothing.

NAD+, ATP, and glutathione are not three separate problems to solve. They are part of an interconnected system that supports cellular energy and antioxidant defense. NAD+ plays an important role in the processes that produce ATP, while NAD-related pathways also help support the processes that keep glutathione in its active form.

That connection is why RiaGev® takes a broader approach to cellular support. Rather than focusing on NAD+ alone, it has been clinically studied for its effects on NAD+, ATP, and glutathione together.

  • Cellular energy
  • Antioxidant defense
  • Studied together
One connected systemTriad
NAD+ fuels ATP ATP regulates NAD+ Glutathione needs NAD+ NAD+ ATP Gluta-thione
Support one and leave two behind — or support all three together.
0
biomarkers raised
in one trial
0
daily tablet for the
complete system
05Why most supplementsMiss the mark

Why Your Last NAD+ Supplement Only Fixed One Biomarker.

NMN and NR are the most marketed NAD+ ingredients right now. The pitch is that they go directly into your cells and raise NAD+ fast. What the research shows is more complicated: they require multiple conversion steps before reaching your cells, reducing how much actually gets through. And even if they did work as advertised, they still do little for ATP and glutathione.

RiaGev® works differently. It goes through the salvage pathway, the route your body already uses and prefers to make NAD+. And it is the only ingredient with published clinical evidence showing improvements in NAD+, ATP, and glutathione in the same study.

NMNNicotinamide mononucleotide
1/5
  • Raises NAD+Yes
  • Raises ATPInconsistent
  • Glutathione supportLimited
  • Sustained releaseNo
  • Salvage pathwayNo
NAD PLUSwith RiaGev®
5/5
  • Raises NAD+Yes
  • Raises ATPYes
  • Glutathione supportYes
  • Sustained releaseYes
  • Salvage pathwayYes
NRNicotinamide riboside
1/5
  • Raises NAD+Yes
  • Raises ATPInconsistent
  • Glutathione supportModerate
  • Sustained releaseNo
  • Salvage pathwayNo

RiaGev® is the only ingredient with published results across all three biomarkers.

06TheDelivery

One Tablet. Three Biomarkers. All Day.

How an ingredient is delivered matters, too. Rather than releasing the full dose at once, NAD PLUS uses a sustained-release format designed to deliver RiaGev® gradually over several hours.

NAD PLUS uses a slow-release vegetable wax tablet to deliver RiaGev® over 5 to 8 hours. No artificial coatings. No stimulants. No sugar coatings. Just one tablet in the morning designed for gradual release throughout the first part of your day.

  • No artificial coatings
  • No stimulants
  • No sugar coatings
Release over an 8-hour daySustained
0h1h2h3h4h5h6h7h8h NAD+ · ATP · Glutathione — all three supported Standard: spike & drop NAD PLUS
A burst isn't support. Your cells need a steady supply.
0–0hrs
steady release
with NAD PLUS
1–2hrs
typical
quick-release
NAD PLUS ReVive + Immune bottle
Start todayNAD PLUS ReVive + Immune

Support All Three Biomarkers, Every Single Day.

Revive your energy. Support your immunity. Daily NAD+ support for energy, immunity & healthy aging.

★★★★★5.0· 5 reviews
  • Sustained cellular energySteady, slow-release nourishment. No spike, no crash
  • Cognitive & metabolic supportBetter focus, sleep and blood sugar balance
  • Normal immune functionVitamin C + glutathione + NAD+ working together
  • Clean formulaNo caffeine, no artificial additives, no niacin flush
90tablets per bottle
70 mgvitamin C added
5–7 hextended release
$37.99$44.99%Save 16% today
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“I like simplicity in my supplements. The NAD PLUS Revive + Immune lets me support immunity and cellular health in one convenient product without multiple bottles or mixes.”

SScottReVive + Immune
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“I've always taken Vitamin C separately, but pairing it with NAD+ support actually makes sense. Energy's been better and I've felt more resilient during travel and work stress.”

ACAmazon CustomerReVive + Immune
★★★★★Verified

“I have been taking this now for about a month. I feel like i have more energy through out the day. I can notice the difference when I forget to take it in the mornings. I will defiantly be ordering this again.”

JCJaden Corbin-MillerNAD PLUS
FAQ

Questions, answered.

NAD+ is the foundation your cells use to produce energy. ATP is the actual fuel your cells spend on every thought and movement. Glutathione is your built-in defense that helps protect cells from oxidative stress. All three are supported by RiaGev® in the same published clinical trial.

In the published trial, glutathione rose 10.2% in just 3 days and ATP was measurably higher by Day 5. Some people notice improvements in energy and focus within the first week. Deeper effects typically build over 2 to 4 weeks of consistent daily use. Individual experiences vary.

Because they are a connected system. NAD+ plays an important role in ATP production. NAD+-related pathways also help support glutathione. Supporting all three provides a broader approach to cellular support.

NMN and NR require multiple conversion steps before reaching your cells, which reduces how much actually gets through. Their results for ATP and glutathione are also limited or inconsistent. RiaGev® works through the pathway your body already prefers for making NAD+, and is the only ingredient with published results across all three biomarkers.

Yes. NAD PLUS is designed for safe daily long-term use. RiaGev®-SR is GRAS affirmed and there is no need to cycle or take breaks.

No. NAD PLUS is completely stimulant free and causes no flushing. The energy comes from your cells running better, not from a stimulant hit.

Anyone in their late 30s or older looking to support cellular energy and healthy aging. It may be especially useful for people looking for a broader approach to NAD+ support that also includes ATP and glutathione.

NAD PLUS · RiaGev®

Three Biomarkers.
One Tablet. Every Day.

Your cells are not running short on willpower. They are running short on the right fuel. NAD PLUS gives them what they need, across all three biomarkers, steadily, every single day.

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NAD PLUS · RiaGev®One tablet · 3 biomarkers · 5–8h release
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